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Solution structure of the LIM-homeodomain transcription factor complex Lhx3/Ldb1 and the effects of a pituitary mutation on key Lhx3 interactions.
Bhati M, Lee C, Gadd MS, Jeffries CM, Kwan A, Whitten AE, Trewhella J, Mackay JP, Matthews JM. Bhati M, et al. PLoS One. 2012;7(7):e40719. doi: 10.1371/journal.pone.0040719. Epub 2012 Jul 25. PLoS One. 2012. PMID: 22848397 Free PMC article.
Here, we use small-angle X-ray scattering of an Ldb1-Lhx3 complex to confirm that in solution the protein is well represented by our previously determined NMR structure as an ensemble of conformers each comprising two well-defined halves (each made up of LIM domain …
Here, we use small-angle X-ray scattering of an Ldb1-Lhx3 complex to confirm that in solution the protein is well represented …
Competition between LIM-binding domains.
Matthews JM, Bhati M, Craig VJ, Deane JE, Jeffries C, Lee C, Nancarrow AL, Ryan DP, Sunde M. Matthews JM, et al. Biochem Soc Trans. 2008 Dec;36(Pt 6):1393-7. doi: 10.1042/BST0361393. Biochem Soc Trans. 2008. PMID: 19021562 Review.
These studies provide an explanation for why Ldb1 binds the LIM domains of the LMO/LIM-HD family, but not LIM domains from other proteins. ...We have also identified an additional LIM interaction domain in one of the LIM-HD proteins, Isl1. Despite low sequence similarity t …
These studies provide an explanation for why Ldb1 binds the LIM domains of the LMO/LIM-HD family, but not LIM domains from other prot …
Kaposi's Sarcoma-Associated Herpesvirus LANA Modulates the Stability of the E3 Ubiquitin Ligase RLIM.
Tadmor H, Greenway M, Ahuja A, Orgil O, Liao G, Ambinder RF, Hayward SD, Shamay M. Tadmor H, et al. J Virol. 2020 Feb 14;94(5):e01578-19. doi: 10.1128/JVI.01578-19. Print 2020 Feb 14. J Virol. 2020. PMID: 31801865 Free PMC article.
Interestingly, we found that LANA enhanced the degradation of some RLIM substrates, such as LDB1 and LMO2, and prevented RLIM-mediated degradation of others, such as LHX3 and TRF1. ...Interestingly, LANA enhanced the degradation of some RLIM substrates, such as L …
Interestingly, we found that LANA enhanced the degradation of some RLIM substrates, such as LDB1 and LMO2, and prevented RLIM-mediate …
LIM Homeodomain (LIM-HD) Genes and Their Co-Regulators in Developing Reproductive System and Disorders of Sex Development.
Singh N, Singh D, Modi D. Singh N, et al. Sex Dev. 2022;16(2-3):147-161. doi: 10.1159/000518323. Epub 2021 Sep 10. Sex Dev. 2022. PMID: 34518474 Free article. Review.
In the mouse genome, there are 13 LIM-HD genes (Lhx1-Lhx9, Isl1-2, Lmx1a-1b), 4 Lmo genes (Lmo1-4), and 2 Ldb genes (Ldb1-2). Amongst these, Lhx1 is required for the development of the mullerian duct epithelium and the timing of the primordial germ cell migration. ...LHX9 …
In the mouse genome, there are 13 LIM-HD genes (Lhx1-Lhx9, Isl1-2, Lmx1a-1b), 4 Lmo genes (Lmo1-4), and 2 Ldb genes (Ldb1-2). Amongst …
LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions.
Thaler JP, Lee SK, Jurata LW, Gill GN, Pfaff SL. Thaler JP, et al. Cell. 2002 Jul 26;110(2):237-49. doi: 10.1016/s0092-8674(02)00823-1. Cell. 2002. PMID: 12150931 Free article.
Using in vivo function and protein interaction assays, we found that Lhx3 binds directly to the LIM cofactor NLI to trigger V2 interneuron differentiation. In motor neurons, however, Isl1 is available to compete for binding to NLI, displacing Lhx3 to a high-affinity …
Using in vivo function and protein interaction assays, we found that Lhx3 binds directly to the LIM cofactor NLI to trigger V2 intern …
Disparate binding kinetics by an intrinsically disordered domain enables temporal regulation of transcriptional complex formation.
Robertson NO, Smith NC, Manakas A, Mahjoub M, McDonald G, Kwan AH, Matthews JM. Robertson NO, et al. Proc Natl Acad Sci U S A. 2018 May 1;115(18):4643-4648. doi: 10.1073/pnas.1714646115. Epub 2018 Apr 16. Proc Natl Acad Sci U S A. 2018. PMID: 29666277 Free PMC article.
An example of this occurs with LIM-homeodomain (LIM-HD) proteins in the developing spinal cord. The LIM-HD protein LHX3 and the LIM-HD cofactor LDB1 form a binary complex that gives rise to interneurons, whereas in adjacent cell populations, LHX3 and LDB1 …
An example of this occurs with LIM-homeodomain (LIM-HD) proteins in the developing spinal cord. The LIM-HD protein LHX3 and the LIM-H …
Characterization of the porcine Lhx3/LIM-3/P-Lim LIM homeodomain transcription factor.
Meier BC, Price JR, Parker GE, Bridwell JL, Rhodes SJ. Meier BC, et al. Mol Cell Endocrinol. 1999 Jan 25;147(1-2):65-74. doi: 10.1016/s0303-7207(98)00213-5. Mol Cell Endocrinol. 1999. PMID: 10195693
We report the cloning and characterization of porcine Lhx3. The porcine Lhx3 protein exhibits strong similarity to murine Lhx3 within the amino terminal LIM domains and the homeodomain, however, it is diverged in regions outside these motifs. ...Together, the …
We report the cloning and characterization of porcine Lhx3. The porcine Lhx3 protein exhibits strong similarity to murine L …
Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes.
Bhati M, Lee C, Nancarrow AL, Lee M, Craig VJ, Bach I, Guss JM, Mackay JP, Matthews JM. Bhati M, et al. EMBO J. 2008 Jul 23;27(14):2018-29. doi: 10.1038/emboj.2008.123. Epub 2008 Jun 26. EMBO J. 2008. PMID: 18583962 Free PMC article.
The additional expression of islet-1 (Isl1) in adjacent cells instead specifies the formation of motor neurons through assembly of a ternary complex in which Isl1 contacts both Lhx3 and Ldb1, displacing Lhx3 as the binding partner of Ldb1. However, lit …
The additional expression of islet-1 (Isl1) in adjacent cells instead specifies the formation of motor neurons through assembly of a ternary …
Structural basis for partial redundancy in a class of transcription factors, the LIM homeodomain proteins, in neural cell type specification.
Gadd MS, Bhati M, Jeffries CM, Langley DB, Trewhella J, Guss JM, Matthews JM. Gadd MS, et al. J Biol Chem. 2011 Dec 16;286(50):42971-80. doi: 10.1074/jbc.M111.248559. Epub 2011 Oct 24. J Biol Chem. 2011. PMID: 22025611 Free PMC article.
Two paralogous pairs of LIM homeodomain proteins, LIM homeobox protein 3/4 (Lhx3/Lhx4) and Islet-1/2 (Isl1/Isl2), are expressed in developing ventral motor neurons. ...We have identified an Lhx3-binding domain (LBD) in Isl2 based on sequence homology with the Isl1(L …
Two paralogous pairs of LIM homeodomain proteins, LIM homeobox protein 3/4 (Lhx3/Lhx4) and Islet-1/2 (Isl1/Isl2), are expressed in de …
16 results